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Health & Science14h 20m ago

New work from the Crick has recorded the missing step in DNA replication, revealing the first image of a pre-initiation complex.

Crick

Who
Alessandro Costa, Thomas Pühringer, John Diffley, and colleagues in Costa's lab at the Crick
What
New work from the Crick has recorded the missing step in DNA replication, revealing the first image of a pre-initiation complex.
When
Thu, 18 Jun 2026 19:00:09 GMT · 14h 20m ago
Where
Crick ·
Why
Cells have evolved careful checks to ensure DNA is copied only once, but how they switch on replication at the right moment has been the focus of a 30-year research question.
The Frontline Impact

How this affects you

This discovery resolves a 30-year mystery in the field of DNA replication, advancing understanding of how faults in this process can lead to cancer and indicating similar strategies are used in yeast and humans.

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