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Health & Science2h 36m ago
A new study has expanded the biological map of substance use disorder, locating a primary genetic driver of cocaine addiction within the liver rather than the brain.
UC San Diego
Who
Dr. Lara, Dr. Palmer, Dr. George, Miles Martin, UC San Diego team, researchers
What
A new study has expanded the biological map of substance use disorder, locating a primary genetic driver of cocaine addiction within the liver rather than the brain.
When
Thu, 11 Jun 2026 20:45:22 GMT · 2h 36m ago
Where
UC San Diego ·
Why
Variations in the Ces1 gene cluster dictate how rapidly an organism breaks down cocaine, directly predicting whether an individual is naturally resistant to or highly susceptible to escalating into compulsive, addictive cycles.
The Frontline Impact
How this affects you
This research suggests a paradigm shift in understanding cocaine addiction, pinpointing liver-based metabolic processes as a key factor and opening up new avenues for drug development that target these liver enzymes instead of brain chemistry to blunt compulsive drug use.
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