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Health & Science2h 38m ago

UC Berkeley researchers developed a laser phase plate, improving cryoelectron microscopy (cryo-EM) to visualize smaller proteins and cellular structures inside cells.

UC Berkeley, Redwood City, California

Who
UC Berkeley physicists, Holger Müller, Bridget Carragher, Robert Glaeser, Stephani Otte
What
UC Berkeley researchers developed a laser phase plate, improving cryoelectron microscopy (cryo-EM) to visualize smaller proteins and cellular structures inside cells.
When
Mon, 15 Jun 2026 07:50:38 GMT · 2h 38m ago
Where
UC Berkeley, Redwood City, California ·
Why
The laser phase plate overcomes signal-to-noise limitations in cryo-EM, previously making most human and animal proteins too small to analyze clearly.
The Frontline Impact

How this affects you

This breakthrough will significantly enhance the visualization of small molecules and proteins in their native environments, accelerating drug discovery and providing unprecedented insights into molecular mechanisms within living cells. It promises to make previously invisible cellular processes visible, fundamentally changing the understanding of disease.

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