Researchers identified distinct full-length isoforms of the CACNA1C gene, a risk gene for psychiatric disorders, expressed in human brain, heart, and aorta.

Human brain, heart, and aorta

Who

Researchers

What

When

Fri, 11 Sep 2026 22:13:37 GMT · 5h 11m ago

Where

Human brain, heart, and aorta ·

Why

Understanding the tissue-specific isoforms of CACNA1C is important for elucidating the molecular mechanisms of psychiatric disorder associations and for developing targeted treatments.

The Frontline Impact

How this affects you

The identification of brain-enriched CACNA1C isoforms offers the potential for designing drugs that preferentially target CaV1.2 channels for psychiatric indications.

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Verified Sources & Citations

Nature
https://www.nature.com/articles/s41380-026-03890-z?error=cookies_not_supported&code=e7ee2f17-d0a0-463c-8260-542c912aaf9a
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